Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | HTR3A | P46098 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | HTR5A | P47898 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149055 | 1.00 | HRH4 (0.51) | HRH4HRH3KDRHTR6HTR3A | |
| Trifluoroacetic Acid SCHEMBL30355123 | 0.88 | HRH4 (0.48) | HRH4HRH3KDRHTR6HTR3A | |
| SCHEMBL9686105 | 0.87 | BRD4 (0.50) | HRH4HRH3KDRKDM4EALDH1A1 | |
| SCHEMBL4543934 | 0.87 | BRD4 (0.50) | HRH4HRH3KDRKDM4EBRD4 | |
| SCHEMBL6582983 | 0.86 | BRD4 (0.49) | HRH3KDRHSD17B10KDM4EALDH1A1 | |
| Lactic Acid SCHEMBL27341609 | 0.83 | HRH4 (0.44) | HRH4HRH3KDRHTR6HTR3A | |
| SCHEMBL13801290 | 0.82 | BRD4 (0.45) | HRH4HRH3KDRHTR3AKDM4E | |
| Phenylpiperazine SCHEMBL27743147 | 0.80 | HTR3E (0.53) | HRH4HRH3KDRHTR6HTR3A | |
| SCHEMBL14410195 | 0.80 | BRD4 (0.46) | HRH4HRH3KDRHTR3ATSHR | |
| SCHEMBL30041257 | 0.77 | HRH4 (0.63) | HRH4HRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808583-A | MICROBIOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | claimed |
| EP-0138018-B1 | SOLUTIONS OF LACTIC ACID SALTS OF PIPERAZINYLQUINOLONE AND PIPERAZINYL AZAQUINOLONECARBOXYLIC ACIDS | BAYER AG (DE) | 1988-11-02 | — | — | EP | claimed |
| US-4705789-A | Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | claimed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |
| US-10350217-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2019-07-16 | — | — | US | disclosed |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2014039515-A2 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-03-13 | — | — | WO | disclosed |
| EP-1401829-B1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX INC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-4808585-A | WITH EXCESS ACID; NONPRECIPITATING | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4808585-A | WITH EXCESS ACID; NONPRECIPITATING | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4808585-A | WITH EXCESS ACID; NONPRECIPITATING | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4808583-A | MICROBIOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4808583-A | MICROBIOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4705789-A | Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| US-4705789-A | Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| US-4705789-A | Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| EP-0138018-A2 | Solutions of lactic acid salts of piperazinylquinolone and piperazinyl azaquinolonecarboxylic acids | BAYER AG (DE) | 1985-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | HRH4 3925/4885HRH3 3538/4885KDR 4688/4885 |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | HRH4 3925/4885HRH3 3538/4885KDR 4688/4885 |
| US-10350217-B2 | Antifungal agents and uses thereof | DPM1, ERG28, SUCLG1 | HRH4 3925/4885HRH3 3538/4885KDR 4688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.