Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | XBP1 | P17861 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459306 | 0.91 | KDR (0.51) | GRK2KDRALDH1A1LMNAMAPT | |
| SCHEMBL967955 | 0.84 | GRK2 (0.45) | GRK2ALDH1A1LMNAMAPTXBP1 | |
| SCHEMBL3460785 | 0.80 | GRK2 (0.47) | GRK2ALDH1A1LMNAMAPTXBP1 | |
| SCHEMBL3459651 | 0.80 | AKT1 (0.56) | LMNAMAPTKMT2AGAAKDM4E | |
| SCHEMBL967953 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1LMNAMAPTXBP1HTT | |
| SCHEMBL963619 | 0.75 | LMNA (0.53) | KDRALDH1A1LMNAMAPTHTT | |
| SCHEMBL966045 | 0.75 | L3MBTL1 (0.47) | GRK2KDRALDH1A1LMNAMAPT | |
| SCHEMBL30366730 | 0.74 | ALDH1A1 (0.61) | GRK2ALDH1A1LMNAMAPTXBP1 | |
| SCHEMBL3460959 | 0.74 | GAA (0.49) | GRK2KDRALDH1A1MAPTXBP1 | |
| SCHEMBL3460011 | 0.73 | GRK2 (0.44) | GRK2ALDH1A1LMNAMAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |