Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1350206 | 0.80 | CARM1 (0.36) | PRKAG1PRKAA1PRKAB1CARM1NTRK1 | |
| SCHEMBL774043 | 0.80 | NTRK1 (0.36) | PRKAG1PRKAA1PRKAB1CARM1NTRK1 | |
| SCHEMBL773567 | 0.80 | CARM1 (0.36) | PRKAG1PRKAA1PRKAB1CARM1NTRK1 | |
| SCHEMBL441643 | 0.79 | RHEB (0.40) | PRKAG1PRKAA1PRKAB1CARM1MEN1 | |
| SCHEMBL14733128 | 0.79 | NTRK1 (0.46) | PRKAG1PRKAA1PRKAB1CARM1NTRK1 | |
| SCHEMBL12138391 | 0.78 | HRH3 (0.36) | PRKAG1PRKAA1PRKAB1CARM1 | |
| SCHEMBL12135912 | 0.78 | HRH3 (0.36) | PRKAG1PRKAA1PRKAB1CARM1 | |
| SCHEMBL768315 | 0.78 | HRH3 (0.36) | PRKAG1PRKAA1PRKAB1CARM1 | |
| SCHEMBL441580 | 0.76 | PRKAG1 (0.36) | PRKAG1PRKAA1PRKAB1NTRK1ACVRL1 | |
| SCHEMBL450332 | 0.76 | PRKAG1 (0.36) | PRKAG1PRKAA1PRKAB1NTRK1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262807-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009117097-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |