Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.65 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332476 | 0.85 | ERCC1 (0.58) | ERCC1ERCC4PPARGHDAC6HDAC1 | |
| SCHEMBL1568038 | 0.84 | L3MBTL1 (0.70) | PPARGEPHX2NR1H4 | |
| SCHEMBL507217 | 0.84 | PPARG (0.56) | ERCC1ERCC4PPARGHDAC6HDAC1 | |
| SCHEMBL20938003 | 0.83 | TSHR (0.69) | HDAC6HDAC1NPC1RAB9AHDAC2 | |
| SCHEMBL30613373 | 0.83 | SMN1; SMN2 (0.67) | ERCC1ERCC4NR1H4ALDH1A1PTGER4 | |
| SCHEMBL31377885 | 0.82 | EPHX2 (0.60) | ERCC1ERCC4PPARGHDAC6HDAC1 | |
| SCHEMBL3026463 | 0.82 | HDAC6 (0.58) | PPARGHDAC6HDAC1EPHX2NR1H4 | |
| SCHEMBL1155517 | 0.81 | ALDH1A1 (0.72) | ERCC1ERCC4HDAC6HDAC1EPHX2 | |
| SCHEMBL11901042 | 0.81 | HDAC6 (0.70) | ERCC1ERCC4PPARGHDAC6HDAC1 | |
| SCHEMBL3569391 | 0.81 | P2RX7 (0.49) | PPARGEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | ERCC1 1909/4885ERCC4 1791/4885PPARG 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.