Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180400 | 0.94 | RXFP1 (0.46) | RXFP1PIK3CDSYKKDM4ECAMK1D | |
| SCHEMBL3459373 | 0.91 | MAPK8 (0.42) | RXFP1PIK3CDSYKKDM4ECTSL | |
| SCHEMBL3461155 | 0.90 | MAPK8 (0.44) | RXFP1CTSLCTSBCTSKBRAF | |
| SCHEMBL3460056 | 0.87 | SMN1; SMN2 (0.40) | PIK3CDKDM4ECTSLCTSBCTSK | |
| SCHEMBL3459877 | 0.86 | MAPK8 (0.41) | RXFP1PIK3CDKDM4ECTSLCTSB | |
| SCHEMBL3459673 | 0.85 | MAPK8 (0.40) | PIK3CDBRAF | |
| SCHEMBL3459370 | 0.85 | ALDH1A1 (0.43) | RXFP1PIK3CDKDM4ELCKTEK | |
| SCHEMBL3459628 | 0.85 | BRAF (0.37) | RXFP1PIK3CDBRAFAURKARPS6KB1 | |
| SCHEMBL3459095 | 0.83 | PIK3CD (0.48) | RXFP1PIK3CDKDM4ECTSLCTSB | |
| SCHEMBL3461151 | 0.83 | MAPK8 (0.44) | RXFP1PIK3CDKDM4EBRAFPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |