Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459370 | 0.93 | ALDH1A1 (0.43) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL3461155 | 0.93 | MAPK8 (0.44) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10180401 | 0.91 | RXFP1 (0.44) | ALDH1A1MAPTCTSLCTSBCTSK | |
| SCHEMBL3460056 | 0.89 | SMN1; SMN2 (0.40) | ALDH1A1MAPTLMNACTSLCTSB | |
| SCHEMBL3459877 | 0.88 | MAPK8 (0.41) | MAPK8ALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL3461151 | 0.87 | MAPK8 (0.44) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL3459095 | 0.85 | PIK3CD (0.48) | ALDH1A1MAPTCTSLCTSBCTSK | |
| SCHEMBL10180400 | 0.85 | RXFP1 (0.46) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3460790 | 0.85 | MAPK8 (0.41) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL3460778 | 0.84 | KDM4E (0.41) | ALDH1A1MAPTLMNACTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |