Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858775 | 0.81 | ALDH1A1 (0.45) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL11853377 | 0.79 | HSD17B10 (0.41) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL22409314 | 0.75 | ALDH1A1 (0.48) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL15846216 | 0.74 | PLCG1 (0.64) | HSD17B10ALDH1A1PLCG1POLBKMT2A | |
| SCHEMBL10424527 | 0.74 | LMNA (0.49) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL11143856 | 0.73 | MAOB (0.46) | HSD17B10LMNAHPGDHIF1AESR1 | |
| SCHEMBL10612173 | 0.72 | LMNA (0.53) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL10626068 | 0.71 | LMNA (0.51) | HSD17B10LMNAHPGDHIF1AALDH1A1 | |
| SCHEMBL2646220 | 0.70 | CA2 (0.53) | HSD17B10LMNAALDH1A1ESR1GAA | |
| SCHEMBL22409172 | 0.69 | SMN1; SMN2 (0.41) | HSD17B10LMNAHPGDHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250150-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009109483-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-11 | — | — | WO | disclosed |