Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 12/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL3460059 | 1.00 | GRIK1 (0.44) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL3859924 | 0.93 | GRIK1 (0.40) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL5441599 | 0.93 | GRIK1 (0.40) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL27137678 | 0.87 | GRIK1 (0.43) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| D-Glutamate SCHEMBL28197267 | 0.81 | GRM8 (0.64) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Cysteine SCHEMBL14956977 | 0.81 | SLC7A11 (0.61) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Cysteine SCHEMBL26928643 | 0.81 | SLC7A11 (0.61) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL11065189 | 0.78 | GRIK1 (0.56) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL1526976 | 0.78 | GRIK1 (0.56) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL3231 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107686554-B | polyaspartic-K-estradiol, its preparation, anti-osteoporosis activity and use | 首都医科大学 | 2021-01-01 | — | — | CN | claimed |
| CN-107686554-A | The poly- female alcohol of asparagus fern K, it is prepared, anti-osteoporosis activity and application | 首都医科大学 | 2018-02-13 | — | — | CN | claimed |
| CN-117425472-A | Enantioselective action on neurotransmission | 小利兰·斯坦福大学托管委员会 | 2024-01-19 | — | — | CN | disclosed |
| CN-107686554-B | polyaspartic-K-estradiol, its preparation, anti-osteoporosis activity and use | 首都医科大学 | 2021-01-01 | — | — | CN | disclosed |
| EP-2023941-B1 | PROTEIN CROSSLINKERS, CROSSLINKING METHODS AND APPLICATIONS THEREOF | INCEPT LLC (US) | 2016-12-21 | — | — | EP | disclosed |
| US-9498557-B2 | Crosslinking methods and applications thereof | INCEPT, LLC (US) | 2016-11-22 | — | — | US | disclosed |
| EP-2197908-A2 | MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS | Dako Denmark A/S (DK) | 2010-06-23 | — | — | EP | disclosed |
| WO-2010037397-A1 | MHC MULTIMERS IN CMV IMMUNE MONITORING | DAKO DENMARK A/S (DK) | 2010-04-08 | — | — | WO | disclosed |
| EP-2155782-A2 | MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES | Dako Denmark A/S (DK) | 2010-02-24 | — | — | EP | disclosed |
| US-20090311338-A1 | CROSSLINKING METHODS AND APPLICATIONS THEREOF | INCEPT LLC | 2009-12-17 | — | — | US | disclosed |
| US-7597882-B2 | Protein crosslinkers, crosslinking methods and applications thereof | INCEPT LLC (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2009039854-A2 | MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS | DAKO DENMARK A/S (DK) | 2009-04-02 | — | — | WO | disclosed |
| EP-2023941-A2 | PROTEIN CROSSLINKERS, CROSSLINKING METHODS AND APPLICATIONS THEREOF | Incept, LLC (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008116468-A2 | MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES | DAKO DENMARK A/S (DK) | 2008-10-02 | — | — | WO | disclosed |
| WO-2007127198-A2 | PROTEIN CROSSLINKERS, CROSSLINKING METHODS AND APPLICATIONS THEREOF | INCEPT, LLC (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070248567-A1 | Protein crosslinkers, crosslinking methods and applications thereof | AUGMENIX, INC. | 2007-10-25 | — | — | US | disclosed |