Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 10/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL5441599 | 1.00 | GRIK1 (0.40) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL27137678 | 0.95 | GRIK1 (0.43) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL3460059 | 0.93 | GRIK1 (0.44) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL3460058 | 0.93 | GRIK1 (0.44) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL7998953 | 0.82 | ALOX15 (0.50) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL366070 | 0.82 | ALOX15 (0.50) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL7998952 | 0.82 | ALOX15 (0.50) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL10011961 | 0.82 | ALOX15 (0.50) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL366069 | 0.82 | ALOX15 (0.50) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| Asparagine SCHEMBL6520765 | 0.80 | ALOX15 (0.48) | GRIK1GRIA2GRIA4GRIK3GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190203119-A1 | Amino Acid, Carbohydrate and Acrylamide Polymers useful as Flocculants in Agricultural and Industrial Settings | AQUERO COMPANY, LLC (US) | 2019-07-04 | — | — | US | disclosed |
| US-9994767-B2 | Amino acid, carbohydrate and acrylamide polymers useful as flocculants in agricultural and industrial settings | AQUERO COMPANY, LLC (US) | 2018-06-12 | — | — | US | disclosed |
| EP-1966347-B1 | CARBOHYDRATE AND ACRYLAMIDE POLYMERS USEFUL AS FLOCCULANTS IN PROCESS WATER OBTAINED FROM AN OIL-SANDS MINING OPERATION | AQUERO COMPANY LLC (US) | 2017-05-03 | — | — | EP | disclosed |
| US-7595002-B2 | Use of amino acid and carbohydrate polymers in soil retention, water conservation, and water clarification | AQUERO COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595007-B2 | Amino acid and carbohydrate polymers for use in soil retention, water conservation, water clarification, and dust control | AQUERO COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-20090127205-A1 | AMINO ACID, CARBOHYDRATE AND ACRYLAMIDE POLYMERS USEFUL AS FLOCCULANTS IN AGRICULTURAL AND INDUSTRIAL SETTINGS | AQUERO COMPANY, LLC | 2009-05-21 | — | — | US | disclosed |
| US-20070084800-A1 | Use of amino acid and carbohydrate polymers in soil retention, water conservation, and water clarification | AQUERO COMPANY, LCC | 2007-04-19 | — | — | US | disclosed |
| US-20070085055-A1 | Amino acid and carbohydrate polymers for use in soil retention, water conservation, water clarification, and dust control | AQUERO COMPANY, LCC | 2007-04-19 | — | — | US | disclosed |