Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 5/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966239 | 0.92 | GAA (0.52) | GAAAHRHSD17B10CCNE1CDK3 | |
| SCHEMBL3460785 | 0.78 | GRK2 (0.47) | GAAMEN1KMT2AGRK2ALDH1A1 | |
| SCHEMBL968750 | 0.76 | KMT2A (0.52) | GAAHSD17B10MEN1KMT2APOLB | |
| SCHEMBL3460011 | 0.75 | GRK2 (0.44) | GAAMEN1KMT2AGRK2ALDH1A1 | |
| SCHEMBL3459310 | 0.74 | GRK2 (0.49) | GAAKDRMEN1KMT2AGRK2 | |
| SCHEMBL965220 | 0.74 | GRK2 (0.47) | GAAMEN1KMT2AGRK2ALDH1A1 | |
| SCHEMBL965312 | 0.74 | GRK2 (0.47) | GAAMEN1KMT2AGRK2ALDH1A1 | |
| SCHEMBL30366730 | 0.73 | ALDH1A1 (0.61) | GAAMEN1KMT2AGRK2ALDH1A1 | |
| SCHEMBL12947024 | 0.72 | LCK (0.50) | GAAKDRMEN1KMT2AALDH1A1 | |
| SCHEMBL967955 | 0.72 | GRK2 (0.45) | GAAMEN1KMT2AGRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |