Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461366 | 0.77 | KDM4E (0.44) | CYP1A2LMNAALDH1A1TLR8CYP2C9 | |
| SCHEMBL3063629 | 0.71 | KDM4E (0.48) | CYP1A2LMNATDP1GAAALDH1A1 | |
| SCHEMBL12737723 | 0.68 | KDM4E (0.50) | CYP1A2TDP1GAAALDH1A1TLR8 | |
| SCHEMBL3349292 | 0.68 | POLB (0.61) | TDP1GAAALDH1A1RAB9AKDM4E | |
| SCHEMBL29488275 | 0.68 | POLB (0.61) | TDP1GAAALDH1A1RAB9AKDM4E | |
| SCHEMBL16681658 | 0.68 | TLR8 (0.54) | CYP1A2ABCB11LMNACYP2D6SCN1A | |
| SCHEMBL1639437 | 0.67 | KDM4E (0.65) | CYP1A2GAAALDH1A1TLR8RAB9A | |
| SCHEMBL29694174 | 0.66 | GPR84 (0.44) | CYP1A2ALDH1A1TLR8RAB9AKDM4E | |
| SCHEMBL644629 | 0.66 | GPR84 (0.44) | CYP1A2ALDH1A1TLR8RAB9AKDM4E | |
| SCHEMBL28620478 | 0.66 | KMT2A (0.51) | CYP1A2LMNAGAAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723337-B2 | 3-cinnolinecarboxamide derivatives and their use for treating cancer | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012084-A1 | 3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | CSF3R, CSF1R, KIT | CYP1A2 3403/4885ABCB11 2781/4885LMNA 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.