Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | CD38 | P28907 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459831 | 0.89 | MAPK8 (0.44) | MAPK8PBRM1CD38HTTKDM4E | |
| SCHEMBL3461564 | 0.79 | MAPK8 (0.49) | MAPK8TAAR1HTTKDM4EGAA | |
| SCHEMBL3461538 | 0.79 | LMNA (0.50) | MAPK8CD38KDM4EKMT2AALDH1A1 | |
| SCHEMBL29836974 | 0.77 | MAPK14 (0.39) | MAPK8HTTKDM4EGAAMAPT | |
| SCHEMBL3460044 | 0.77 | L3MBTL1 (0.46) | KDM4EGAATP53TDP1MAPT | |
| SCHEMBL7134588 | 0.75 | TSHR (0.54) | KDM4EGAATDP1MAPTKMT2A | |
| SCHEMBL27616376 | 0.73 | HTT (0.54) | TAAR1BACE1HTTGAATDP1 | |
| SCHEMBL3460903 | 0.73 | MAPK14 (0.51) | MAPK8HTTLMNA | |
| SCHEMBL3935646 | 0.73 | KMT2A (0.58) | MAPK8TAAR1BACE1HTTKDM4E | |
| SCHEMBL27837954 | 0.72 | PLA2G2A (0.47) | MAPK8CD38TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | MAPK8 224/4885PBRM1 1502/4885CD38 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.