Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | EIF4E | P06730 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 3/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000140 | 0.83 | EIF4E (0.45) | EIF4EMAOBMAOAVCAM1ADRA2C | |
| SCHEMBL5605382 | 0.78 | TDP1 (0.69) | GPR35CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL2405410 | 0.78 | GPR35 (0.55) | GPR35CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL16120016 | 0.77 | EIF4E (0.53) | EIF4EMAOBMAOAVCAM1XDH | |
| SCHEMBL24909406 | 0.77 | VCAM1 (0.44) | GPR35MAOBMAOAVCAM1CRHBP | |
| Bromide SCHEMBL4334733 | 0.77 | GPR35 (0.53) | GPR35CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL7949875 | 0.76 | CLK1 (0.46) | EIF4EVCAM1 | |
| SCHEMBL11309776 | 0.76 | GPR35 (0.78) | GPR35CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL408308 | 0.75 | ERN1 (0.59) | GPR35CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL31415060 | 0.75 | ERN1 (0.59) | GPR35CRHBPCRHR2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160644-A1 | NOVEL PROCESSES OF MAKING HYDROXY-1-AZO-DERIVATIVES AS TPO MIMETICS | SMITHKLINE BEECHAM CORPORATION | 2010-06-24 | — | — | US | disclosed |
| US-20100160644-A1 | NOVEL PROCESSES OF MAKING HYDROXY-1-AZO-DERIVATIVES AS TPO MIMETICS | SMITHKLINE BEECHAM CORPORATION | 2010-06-24 | — | — | US | disclosed |
| US-20100160644-A1 | NOVEL PROCESSES OF MAKING HYDROXY-1-AZO-DERIVATIVES AS TPO MIMETICS | SMITHKLINE BEECHAM CORPORATION | 2010-06-24 | — | — | US | disclosed |
| WO-2008134338-A1 | NOVEL PROCESSES OF MAKING HYDROXY-1-AZO-DERIVATIVES AS TPO MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160644-A1 | NOVEL PROCESSES OF MAKING HYDROXY-1-AZO-DERIVATIVES AS TPO MIMETICS | TPO, MPL, THPO | GPR35 2712/4885EIF4E 4762/4885MAOB 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.