Sugi Predict

Sugi Predict / Compounds / SCHEMBL346324

SCHEMBL346324

SCHEMBL346324

CCOC(=O)c1cc(CCO)on1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 4/20 0.48
▸ ALDH1A1 P00352 4/20 0.48
▸ HSD17B10 Q99714 3/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ CYP1A2 P05177 1/20 0.45
▸ RAB9A P51151 4/20 0.44
▸ MAPT P10636 2/20 0.44
▸ TP53 P04637 1/20 0.43
▸ SMN1; SMN2 Q16637 3/20 0.43
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ NPC1 O15118 3/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ TSHR P16473 2/20 0.41
▸ STAT3 P40763 1/20 0.40
▸ ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15932116 0.91 CYP4F2 (0.47) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL15931948 0.89 HPGD (0.46) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL15931414 0.89 HPGD (0.58) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL15931827 0.88 HPGD (0.45) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL15931828 0.88 HPGD (0.45) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL345384 0.87 TP53 (0.48) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL31644605 0.86 HPGD (0.47) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL9259869 0.86 HPGD (0.47) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL15931887 0.86 HPGD (0.50) HPGDALDH1A1HSD17B10KDM4ECYP1A2
SCHEMBL6371541 0.85 MAPT (0.56) HPGDALDH1A1HSD17B10KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133989-A1 SMYD MODULATORS AND USES THEREOF ALT-BIO PTE. LTD. (SG) 2025-06-26 — — WO disclosed
EP-4522615-A1 LRRK2 INHIBITORS Interline Therapeutics, Inc. (US) 2025-03-19 — — EP disclosed
CN-119546607-A LRRK2 inhibitors 因特来治疗公司 2025-02-28 — — CN disclosed
US-20250066356-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. 2025-02-27 — — US disclosed
WO-2023220238-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. (US) 2023-11-16 — — WO disclosed
WO-2023220238-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. (US) 2023-11-16 — — WO disclosed
US-20200148650-A1 ISOXAZOLE CARBOXAMIDE COMPOUNDS Epizyme, Inc. 2020-05-14 — — US disclosed
US-20200148650-A1 ISOXAZOLE CARBOXAMIDE COMPOUNDS Epizyme, Inc. 2020-05-14 — — US disclosed
US-10428029-B2 Isoxazole carboxamide compounds Epizyme, Inc. (US) 2019-10-01 — — US disclosed
US-10428029-B2 Isoxazole carboxamide compounds Epizyme, Inc. (US) 2019-10-01 — — US disclosed
WO-2016040498-A1 ISOXAZOLE CARBOXAMIDE COMPOUNDS Epizyme, Inc. (US) 2016-03-17 — — WO disclosed
US-8716289-B2 Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-05-06 — — US disclosed
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2012-01-19 — — US disclosed
EP-1704143-A1 MALONONITRILE COMPOUND AS PESTICIDES Sumitomo Chemical Company, Limited (JP) 2006-09-27 — — EP disclosed
WO-2005068432-A1 MALONONITRILE COMPOUND AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-07-28 — — WO disclosed
EP-0986562-B1 SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME (GB) 2002-08-07 — — EP disclosed
US-6310203-B1 Precursor compounds to substituted 1,2,4-triazolo[3,4,-a]phathalazine GABA alpha 5 ligands MERCK SHARPE & DOHME LIMITED (GB) 2001-10-30 — — US disclosed
US-6200975-B1 FOR COGNITION ENHANCEMENT THERAPY MERCK SHARP & DOHME LIMITED (GB) 2001-03-13 — — US disclosed
EP-0986562-A1 SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LTD. (GB) 2000-03-22 — — EP disclosed
WO-1998050385-A1 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1998-11-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10428029-B2 Isoxazole carboxamide compounds SMYD3, SMYD2, SNRPD3 HPGD 3491/4885ALDH1A1 1259/4885HSD17B10 3299/4885
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF INTS9, CDK8, SCN8A HPGD 2068/4885ALDH1A1 2486/4885HSD17B10 1436/4885
US-20250066356-A1 LRRK2 INHIBITORS LRRK2, PARK7, PINK1 HPGD 2131/4885ALDH1A1 2142/4885HSD17B10 3433/4885
US-20200148650-A1 ISOXAZOLE CARBOXAMIDE COMPOUNDS SMYD3, SMYD2, SNRPD3 HPGD 3589/4885ALDH1A1 1132/4885HSD17B10 3180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.