Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743695 | 0.83 | ADRA2A (0.37) | KDM1AADRA2ACYP11B2LMNACYP19A1 | |
| SCHEMBL3464936 | 0.82 | CYP19A1 (0.35) | CYP11B2CYP19A1DRD2DRD3 | |
| SCHEMBL3464420 | 0.82 | CYP11B2 (0.35) | KDM1ACYP11B2CYP19A1SIGMAR1DRD2 | |
| SCHEMBL3466178 | 0.75 | CYP19A1 (0.60) | KDM1ACYP11B2CYP19A1CYP11B1 | |
| SCHEMBL13564610 | 0.73 | CYP19A1 (0.58) | KDM1ACYP11B2CYP19A1CYP11B1 | |
| SCHEMBL1129300 | 0.68 | KDM1A (0.40) | KDM1AADRA2ACYP11B2LMNACYP3A4 | |
| SCHEMBL3464978 | 0.68 | KDM1A (0.42) | KDM1AADRA2ALMNACYP3A4CYP2C19 | |
| SCHEMBL3465912 | 0.66 | CYP19A1 (0.55) | CYP11B2CYP19A1CYP11B1 | |
| SCHEMBL4640481 | 0.66 | KDM1A (0.61) | KDM1AADRA2ALMNACYP2C19SIGMAR1 | |
| SCHEMBL3464404 | 0.66 | CYP19A1 (0.36) | CYP11B2CYP19A1DRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168145-A1 | FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168145-A1 | FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS | CYP21A2, CYP11B1, CYP17A1 | KDM1A 2819/4885ADRA2A 379/4885CYP11B2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.