Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.81 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CLPP | Q16740 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463896 | 1.00 | CYP11B2 (0.81) | CYP11B2CYP11B1MITFPKMHTT | |
| SCHEMBL3464675 | 0.80 | CYP11B2 (0.70) | CYP11B2CYP11B1 | |
| SCHEMBL3464672 | 0.80 | CYP11B2 (0.70) | CYP11B2CYP11B1 | |
| SCHEMBL3464837 | 0.79 | CYP11B2 (0.62) | CYP11B2CYP11B1 | |
| SCHEMBL3464840 | 0.79 | CYP11B2 (0.62) | CYP11B2CYP11B1 | |
| SCHEMBL3978769 | 0.78 | CYP11B2 (0.54) | CYP11B2CYP11B1MITFPKMHTT | |
| SCHEMBL3981385 | 0.77 | CYP11B2 (0.56) | CYP11B2CYP11B1MITFPKMHTT | |
| SCHEMBL3984392 | 0.77 | CYP11B2 (0.58) | CYP11B2CYP11B1MITFPKMHTT | |
| SCHEMBL4269316 | 0.74 | CYP11B2 (0.53) | CYP11B2CYP11B1MITFPKMHTT | |
| SCHEMBL8360550 | 0.73 | CYP11B2 (0.55) | CYP11B2CYP11B1NPSR1SCN9AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240641-A1 | Aldosterone Synthase and/or 11B-hydroxylase Inhibitors | PAPILLON JULIEN | 2010-09-23 | — | — | US | disclosed |
| EP-2029604-A2 | ALDOSTERONE SYNTHASE AND/OR 11BETA-HYDROXYLASE INHIBITORS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139992-A2 | ALDOSTERONE SYNTHASE AND/OR 11β-HYDROXYLASE INHIBITORS | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240641-A1 | Aldosterone Synthase and/or 11B-hydroxylase Inhibitors | HSD11B1, HSD11B2, CYP11B1 | CYP11B2 4/4885CYP11B1 3/4885MITF 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.