Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464573 | 1.00 | MAPT (0.53) | MAPTTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL13504656 | 0.88 | TDP1 (0.54) | TDP1MEN1KMT2AGAACA12 | |
| SCHEMBL28922732 | 0.87 | TDP1 (0.53) | TDP1MEN1KMT2AGAACA12 | |
| SCHEMBL18355345 | 0.84 | CA12 (0.52) | MAPTTDP1MEN1KMT2AGAA | |
| SCHEMBL30324855 | 0.83 | CA12 (0.49) | MAPTTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL3464768 | 0.82 | TDP1 (0.55) | TDP1MEN1KMT2AGAACA12 | |
| SCHEMBL2089332 | 0.82 | MAPT (0.42) | MAPTTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL31449935 | 0.82 | MAPT (0.42) | MAPTTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL5199651 | 0.82 | MEN1 (0.55) | TDP1MEN1KMT2AGAACA12 | |
| SCHEMBL1909823 | 0.82 | MAPT (0.42) | MAPTTDP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111391-B9 | NEW UNSATURATED FATTY AMINO-ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY | FABRE PIERRE DERMO COSMETIQUE (FR) | 2013-05-29 | — | — | EP | claimed |
| EP-2111391-B1 | NEW UNSATURATED FATTY AMINO-ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY | FABRE PIERRE DERMO COSMETIQUE (FR) | 2012-10-31 | — | — | EP | claimed |
| US-20100240754-A1 | UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY | Pierre Fabre Demo-Cosmetique (FR) | 2010-09-23 | — | — | US | claimed |
| US-9868717-B2 | Tricyclic sulphonamide compounds and methods of making and using same | ZAFGEN, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| EP-2925737-B1 | TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY | ZAFGEN INC (US) | 2017-06-14 | — | — | EP | disclosed |
| US-20160083362-A1 | TRICYCLIC SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2016-03-24 | — | — | US | disclosed |
| EP-2925737-A1 | TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY | Zafgen, Inc. (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014071369-A1 | TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY | ZAFGEN, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083362-A1 | TRICYCLIC SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | DNPEP, ANPEP, METAP2 | MAPT 2284/4885TDP1 1451/4885ALDH1A1 1175/4885 |
| US-20100240754-A1 | UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY | FFAR3, FFAR2, BCAT1 | MAPT 4864/4885TDP1 3910/4885ALDH1A1 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.