Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466053 | 0.86 | PTGDR2 (0.46) | PTGDR2RAB9AALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3463844 | 0.75 | LMNA (0.42) | PTGDR2RAB9AALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3463954 | 0.74 | MEN1 (0.50) | ALDH1A1HSD17B10GAA | |
| SCHEMBL3463168 | 0.72 | ALDH1A1 (0.45) | PTGDR2RAB9AALDH1A1HSD17B10ALOX15 | |
| SCHEMBL13024306 | 0.71 | KMT2A (0.65) | ALDH1A1GAA | |
| SCHEMBL13162715 | 0.71 | ALDH1A1 (0.44) | PTGDR2RAB9AALDH1A1HSD17B10ALOX15 | |
| SCHEMBL111808 | 0.70 | ALDH1A1 (0.67) | PTGDR2ALDH1A1GAA | |
| SCHEMBL2984091 | 0.68 | ALDH1A1 (0.41) | PTGDR2RAB9AALDH1A1GAA | |
| SCHEMBL13163211 | 0.68 | MEN1 (0.51) | PTGDR2ALDH1A1HSD17B10GAA | |
| SCHEMBL3464010 | 0.67 | ALDH1A1 (0.53) | PTGDR2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| CN-100542534-C | Substituted piperazines | CHEMOCENTRYX INC (US) | 2009-09-23 | — | — | CN | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060106218-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20050256130-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2005-11-17 | — | — | US | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106218-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | PTGDR2 164/4885RAB9A 4163/4885ALDH1A1 951/4885 |
| US-20050256130-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | PTGDR2 164/4885RAB9A 4163/4885ALDH1A1 951/4885 |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | PTGDR2 164/4885RAB9A 4163/4885ALDH1A1 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.