⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482982 | 0.93 | FAAH (0.68) | — | |
| SCHEMBL12757512 | 0.91 | FAAH (0.72) | — | |
| SCHEMBL11792171 | 0.91 | FAAH (0.72) | — | |
| SCHEMBL9618659 | 0.87 | FAAH (0.81) | — | |
| SCHEMBL12346213 | 0.87 | FAAH (0.73) | — | |
| SCHEMBL13268369 | 0.84 | FAAH (0.86) | — | |
| SCHEMBL499113 | 0.84 | — | — | |
| SCHEMBL10064157 | 0.84 | FAAH (0.86) | — | |
| SCHEMBL292097 | 0.82 | — | — | |
| SCHEMBL9432120 | 0.81 | NAAA (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074887-A1 | PHARMACEUTICAL COMPOSITIONS OF 6-(2-(2H-TETRAZOL-5-YL)ETHYL)DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND DERIVATIVES THEREOF | Sea Pharmaceuticals LLC. (US) | 2025-03-06 | — | — | US | disclosed |
| EP-4444691-A1 | EXTRACTION OF POLYHYDROXYALKANOATES FROM BIOMASS, AND USES THEREOF | Hes-so Valais-wallis (CH) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023130008-A2 | PHARMACEUTICAL COMPOSITIONS OF 6-(2-(2H-TETRAZOL-5-YL)ETHYL)DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND DERIVATIVES THEREOF | SEA PHARMACEUTICALS LLC (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2023130008-A2 | PHARMACEUTICAL COMPOSITIONS OF 6-(2-(2H-TETRAZOL-5-YL)ETHYL)DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND DERIVATIVES THEREOF | SEA PHARMACEUTICALS LLC (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2023104316-A1 | EXTRACTION OF POLYHYDROXYALKANOATES FROM BIOMASS, AND USES THEREOF | HES-SO VALAIS-WALLIS (CH) | 2023-06-15 | — | — | WO | disclosed |
| EP-3497103-B1 | PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS | PFIZER (US) | 2021-05-05 | — | — | EP | disclosed |
| US-7786307-B2 | suchas N-(4(S)-amino-5(S)-hydroxy-2(S)-isopropyl-6-piperidin-1-ylhexyl)-2-(3-methoxypropoxy)benzamide dihydrochloride, used for the treatment of hypertension, cardiovasculr disorders, complications owing to diabetes, vision deffects, hyperaldosteronism, states of anxiety and cognitive disorders | NOVARTIS AG (CH) | 2010-08-31 | — | — | US | disclosed |
| US-20070155743-A1 | Amino alcohol derivatives and their activity as renin inhibitors | NOVARTIS PHARMA AG (CH) | 2007-07-05 | — | — | US | disclosed |
| US-7230144-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1756037-A2 | AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS | Speedel Experimenta AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| US-6844447-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2005-01-18 | — | — | US | disclosed |
| WO-2003103652-A1 | METHODS OF TREATING ALZHEIMER’S DISEASE USING AROMATICALLY SUBSTITUTED ω-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES | ELAN PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |
| US-20030162851-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-28 | — | — | US | disclosed |
| US-20030158274-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-21 | — | — | US | disclosed |
| US-20030158441-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-21 | — | — | US | disclosed |
| US-20030144551-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-07-31 | — | — | US | disclosed |
| WO-2003051813-A1 | METHODS OF MAKING INTERMEDIATES FROM POLYHYDROXYALKANOATES | METABOLIX, INC. (US) | 2003-06-26 | — | — | WO | disclosed |
| US-5641778-A | EXHIBIT RENIN-INHIBITING PROPERTIES AND CAN BE USED AS ANTIHYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0716077-A1 | Aromatically substituted omega amino alcanoic acid amides and alcanoic diamides and their use as renine inhibitors | CIBA-GEIGY AG (CH) | 1996-06-12 | — | — | EP | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |