Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467002 | 0.89 | LMNA (0.54) | BRAFSYKTTKLMNAMEN1 | |
| SCHEMBL3466290 | 0.88 | KIT (0.46) | BRAFSYKTTKLMNAMEN1 | |
| SCHEMBL3466032 | 0.86 | RAD52 (0.49) | BRAFTTKKITDDR1ABL1 | |
| SCHEMBL3466303 | 0.85 | GAA (0.53) | BRAFSYKTTKLMNAMEN1 | |
| SCHEMBL3469213 | 0.85 | FYN (0.55) | BRAFSYKTTKLMNAMEN1 | |
| SCHEMBL14537038 | 0.84 | TTK (0.48) | BRAFAURKASYKTTKFGFR3 | |
| SCHEMBL3469410 | 0.83 | RAD52 (0.62) | BRAF | |
| SCHEMBL8246984 | 0.83 | FYN (0.54) | BRAFAURKASYKTTKFGFR3 | |
| SCHEMBL3465843 | 0.83 | LMNA (0.43) | BRAFSYKTTKLMNAMEN1 | |
| SCHEMBL3466278 | 0.82 | FYN (0.47) | BRAFAURKASYKTTKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |