Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 7/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.50 |
| ▸ | KIT | P10721 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | BCR | P11274 | 4/20 | 0.50 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 3/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467932 | 0.91 | DDR1 (0.47) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3465798 | 0.89 | BRAF (0.51) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3466290 | 0.89 | KIT (0.46) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3466032 | 0.88 | RAD52 (0.49) | DDR1DDR2KITABL1BCR | |
| SCHEMBL3469410 | 0.87 | RAD52 (0.62) | BRAFRAD52PAX8 | |
| SCHEMBL3469213 | 0.85 | FYN (0.55) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3466303 | 0.84 | GAA (0.53) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3466278 | 0.82 | FYN (0.47) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3466587 | 0.82 | MAPT (0.52) | LMNAPOLBDDR1DDR2KIT | |
| SCHEMBL3467351 | 0.82 | FYN (0.55) | DDR1DDR2KITABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |