Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467002 | 0.82 | LMNA (0.54) | BRAFLMNAPOLBSYKABL1 | |
| SCHEMBL3466303 | 0.82 | GAA (0.53) | MAPTBRAFLMNAARPOLB | |
| SCHEMBL3469213 | 0.82 | FYN (0.55) | BRAFLMNAPOLBSYKABL1 | |
| SCHEMBL3467043 | 0.81 | ABCG2 (0.54) | MAPTBRAFLMNAPOLBEGFR | |
| SCHEMBL3465711 | 0.81 | SYK (0.45) | MAPTBRAFLMNAARPOLB | |
| SCHEMBL3465798 | 0.80 | BRAF (0.51) | BRAFLMNAARAURKAPOLB | |
| SCHEMBL3466944 | 0.80 | DYRK1A (0.44) | BRAFLMNAARPOLBSYK | |
| SCHEMBL3465843 | 0.80 | LMNA (0.43) | MAPTBRAFLMNAARPOLB | |
| SCHEMBL3466290 | 0.80 | KIT (0.46) | BRAFLMNAPOLBSYKABL1 | |
| SCHEMBL3466278 | 0.79 | FYN (0.47) | MAPTBRAFLMNAAURKAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |