Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22636672 | 0.78 | CYP1A2 (0.36) | CYP3A4CYP1A2CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL5273162 | 0.77 | CYP3A4 (0.36) | CYP3A4CYP1A2CYP2D6CTSDBACE1 | |
| SCHEMBL3467143 | 0.76 | SIRT3 (0.42) | CYP3A4CYP1A2CYP2D6TDP1NTRK1 | |
| SCHEMBL22636629 | 0.75 | TDO2 (0.46) | CYP3A4CYP1A2CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL29430749 | 0.75 | TDO2 (0.46) | CYP3A4CYP1A2CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL5550508 | 0.75 | FEN1 (0.48) | — | |
| SCHEMBL3467346 | 0.74 | HSD17B1 (0.47) | CYP3A4CYP2D6ALDH1A1TDP1CASP1 | |
| SCHEMBL31661348 | 0.73 | CYP3A4 (0.62) | CYP3A4ALDH1A1TDP1CASP1TSHR | |
| SCHEMBL6866139 | 0.73 | CYP3A4 (0.62) | CYP3A4ALDH1A1TDP1CASP1TSHR | |
| SCHEMBL9290080 | 0.72 | CYP1A2 (0.53) | CYP3A4CYP1A2CYP2D6ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |