Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899400 | 0.85 | ALDH1A1 (0.59) | HSD17B1HSD17B2RAB9ATSHRHSD17B10 | |
| SCHEMBL12230849 | 0.82 | PGR (0.47) | HSD17B1HSD17B2HSD17B10HDAC1HDAC2 | |
| SCHEMBL11896432 | 0.78 | ALDH1A1 (0.53) | RAB9ATSHRHSD17B10HDAC1HDAC2 | |
| SCHEMBL3468208 | 0.78 | PGR (0.48) | HSD17B1HSD17B2RAB9ATSHRHSD17B10 | |
| SCHEMBL278994 | 0.77 | HDAC1 (0.45) | HSD17B1HSD17B2RAB9ATSHRHSD17B10 | |
| SCHEMBL31661348 | 0.76 | CYP3A4 (0.62) | RAB9ATSHRHSD17B10ALDH1A1TDP1 | |
| SCHEMBL6866139 | 0.76 | CYP3A4 (0.62) | RAB9ATSHRHSD17B10ALDH1A1TDP1 | |
| SCHEMBL9927249 | 0.76 | APP (0.48) | HSD17B1HSD17B2RAB9AHSD17B10PGR | |
| SCHEMBL2608311 | 0.75 | PGR (0.62) | HSD17B1HSD17B2RAB9AHSD17B10HDAC1 | |
| SCHEMBL11896154 | 0.75 | APP (0.70) | HSD17B1HSD17B2RAB9AHSD17B10HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |