SCHEMBL3467372

SCHEMBL3467372

CC(Oc1ccc(Cl)cc1)c1nnc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.56
HSD17B10 Q99714 2/20 0.56
CA1 P00915 2/20 0.47
MAPT P10636 3/20 0.45
HPGD P15428 2/20 0.45
PKM P14618 2/20 0.45
KDM1A O60341 2/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
LMNA P02545 1/20 0.44
ALOX12 P18054 1/20 0.44
HTT P42858 1/20 0.44
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
TSHR P16473 1/20 0.42
SCN3A Q9NY46 1/20 0.42
PGR P06401 1/20 0.41
MAOA P21397 1/20 0.41
SCN1A P35498 2/20 0.41
SCN5A Q14524 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3467562 0.92 ALDH1A1 (0.54) ALDH1A1HSD17B10CA1MAPTHPGD
SCHEMBL3468523 0.84 ALDH1A1 (0.52) ALDH1A1HSD17B10CA1MAPTKDM1A
SCHEMBL3467037 0.83 ALDH1A1 (0.56) ALDH1A1HSD17B10CA1MAPTHPGD
SCHEMBL3467984 0.82 ALDH1A1 (0.52) ALDH1A1HSD17B10CA1MAPTHPGD
SCHEMBL3467587 0.79 ALDH1A1 (0.52) ALDH1A1HSD17B10CA1MAPTHPGD
SCHEMBL5404610 0.76 ALDH1A1 (0.71) ALDH1A1HSD17B10CA1MAPTKDM1A
SCHEMBL3466833 0.76 ALDH1A1 (0.54) ALDH1A1HSD17B10MAPTHPGDPKM
SCHEMBL3467359 0.74 ALDH1A1 (0.52) ALDH1A1CA1MAPTPKMMEN1
SCHEMBL3467234 0.74 MEN1 (0.48) ALDH1A1HSD17B10CA1MEN1KMT2A
SCHEMBL3467310 0.74 MEN1 (0.43) ALDH1A1CA1MAPTHPGDPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010073011-A2 COMPOUNDS USEFUL AS MEDICAMENTS BETAGENON AB (SE) 2010-07-01 WO disclosed