Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21052503 | 0.78 | AHR (0.36) | CA1CA2CA9GAA | |
| SCHEMBL26601688 | 0.78 | — | — | |
| SCHEMBL21356184 | 0.76 | AHR (0.32) | — | |
| SCHEMBL29384228 | 0.76 | AHR (0.32) | — | |
| SCHEMBL3344291 | 0.75 | GAA (0.33) | CA1CA2CA9GAA | |
| SCHEMBL27749404 | 0.73 | ALDH1A1 (0.32) | — | |
| SCHEMBL4591472 | 0.72 | GAA (0.40) | CA1CA2CA9GAA | |
| SCHEMBL3468380 | 0.72 | MEN1 (0.34) | GAA | |
| SCHEMBL29951151 | 0.71 | TDP1 (0.42) | CA1CA2CA9GAA | |
| SCHEMBL3467784 | 0.71 | CYP3A4 (0.48) | CA1CA2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010072599-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |