SCHEMBL3467784

SCHEMBL3467784

Nc1ccc(Cl)c(CC=O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.48
TSHR P16473 2/20 0.48
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
ALDH1A1 P00352 6/20 0.38
ALOX15 P16050 2/20 0.38
THRB P10828 1/20 0.38
HPGD P15428 1/20 0.38
CASP1 P29466 1/20 0.38
RECQL P46063 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HTR2A P28223 1/20 0.37
SLC6A4 P31645 1/20 0.37
BCL2L1 Q07817 1/20 0.35
TDP1 Q9NUW8 2/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TAAR1 Q96RJ0 2/20 0.33
PDE7A Q13946 1/20 0.33
SYK P43405 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL479743 0.86 CYP3A4 (0.46) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL3507727 0.81 TDP1 (0.43) CYP3A4TSHRALDH1A1ALOX15HPGD
SCHEMBL20819282 0.79 CYP3A4 (0.48) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL16670732 0.79 CSNK2A1 (0.41) TAAR1PNMT
SCHEMBL282088 0.78 CYP3A4 (0.52) CYP3A4TSHRCA1CA2ALDH1A1
SCHEMBL15358717 0.78 CASP1 (0.39) CYP3A4TSHRALDH1A1ALOX15THRB
SCHEMBL9939734 0.78 HTR2A (0.39) CYP3A4ALDH1A1HPGDHTR2ASLC6A4
SCHEMBL3454581 0.78 ALDH1A1 (0.37) ALDH1A1HPGDHTR2ASLC6A4SMN1; SMN2
SCHEMBL29956098 0.78 HTR2A (0.39) CYP3A4ALDH1A1HPGDHTR2ASLC6A4
SCHEMBL14744357 0.76 CSNK2A2 (0.47) CYP3A4TSHRCA1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2794573-A1 NOVEL INSECTICIDAL AROMATIC AMIDES Bayer Intellectual Property GmbH (DE) 2014-10-29 EP disclosed
WO-2013092522-A1 NOVEL INSECTICIDAL AROMATIC AMIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-27 WO disclosed
EP-2393781-A1 DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS F. Hoffmann-La Roche AG (CH) 2011-12-14 EP disclosed
WO-2010072599-A1 DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2010-07-01 WO disclosed
EP-1745041-A2 QUINOXALINE INHIBITORS OF THE HEDGEHOG SIGNALLING PATHWAY Genentech, Inc. (US) 2007-01-24 EP disclosed
WO-2006078283-A2 QUINOXALINE INHIBITORS OF HEDGEHOG SIGNALLING GENENTECH, INC. (US) 2006-07-27 WO disclosed