Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469340 | 0.81 | FYN (0.62) | TTKFYNRAD52 | |
| SCHEMBL25013801 | 0.80 | TTK (0.57) | TTKAURKA | |
| SCHEMBL4394379 | 0.78 | TTK (0.49) | TTKAURKAALDH1A1RAD52 | |
| SCHEMBL3469358 | 0.78 | TTK (0.49) | TTKFYNRAD52 | |
| SCHEMBL25014253 | 0.77 | TTK (0.56) | TTKAURKAALDH1A1 | |
| SCHEMBL14164724 | 0.76 | AURKA (0.49) | TTKAURKAKMT2ATDP1MEN1 | |
| SCHEMBL14240757 | 0.76 | AURKA (0.50) | TTKAURKAFYNKMT2AMEN1 | |
| SCHEMBL4338168 | 0.75 | PIM1 (0.62) | AURKAFYNKMT2ATDP1MEN1 | |
| SCHEMBL25013288 | 0.74 | TTK (0.47) | TTK | |
| SCHEMBL5576245 | 0.74 | TTK (0.54) | TTKTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |