Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.69 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.53 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310995 | 0.88 | KIF11 (0.70) | KIF11CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL30122307 | 0.85 | KIF11 (0.73) | KIF11MAPTSMN1; SMN2MAOAMAOB | |
| SCHEMBL28956489 | 0.85 | KIF11 (0.73) | KIF11MAPTSMN1; SMN2MAOAMAOB | |
| SCHEMBL24314993 | 0.83 | CYP1A2 (0.70) | KIF11CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL16208447 | 0.81 | KIF11 (1.00) | KIF11MAPTSMN1; SMN2 | |
| SCHEMBL3315694 | 0.80 | KIF11 (0.79) | KIF11CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL3466905 | 0.80 | OTUD7B (0.52) | KIF11CYP11B1CYP11B2OTUD7BGRIA1 | |
| SCHEMBL24314020 | 0.79 | CYP11B1 (0.55) | KIF11CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL3309677 | 0.78 | KIF11 (0.62) | KIF11CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL6968452 | 0.77 | HRH3 (0.57) | CYP11B1CYP11B2CYP1A2OTUD7BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |