Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.53 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3308412 | 0.91 | KIF11 (0.53) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL4891219 | 0.87 | KIF11 (0.56) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL3467592 | 0.85 | KIF11 (0.52) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL3468115 | 0.83 | KIF11 (0.47) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL4594888 | 0.82 | KIF11 (0.56) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL3467771 | 0.81 | KIF11 (0.48) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL3467252 | 0.81 | KIF11 (0.53) | KIF11TDP2CDK2AKT1CDK1 | |
| SCHEMBL3467357 | 0.81 | AKR1C3 (0.45) | KIF11FFAR1PPARDPPARA | |
| SCHEMBL3466969 | 0.81 | S1PR5 (0.43) | KIF11RXRARXRBRXRG | |
| SCHEMBL3713898 | 0.81 | KMT2A (0.43) | KIF11TDP2DGAT1KMT2APPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |