Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467352 | 0.89 | KIF11 (0.45) | KIF11ADRB1ADRB3RXRAP2RY14 | |
| SCHEMBL3467503 | 0.88 | KIF11 (0.44) | KIF11ADRB1ADRB3CDK1KIT | |
| SCHEMBL3468263 | 0.83 | KIF11 (0.53) | KIF11ADRB1ADRB3RXRARXRB | |
| SCHEMBL3308412 | 0.83 | KIF11 (0.53) | KIF11ADRB1ADRB3RXRARXRB | |
| SCHEMBL4891219 | 0.81 | KIF11 (0.56) | KIF11ADRB1ADRB3P2RY14TMEM97 | |
| SCHEMBL3467592 | 0.80 | KIF11 (0.52) | KIF11ADRB1ADRB3CDK1KIT | |
| SCHEMBL3467348 | 0.79 | KIF11 (0.41) | KIF11FFAR1 | |
| SCHEMBL4594888 | 0.77 | KIF11 (0.56) | KIF11ADRB1ADRB3P2RY14TMEM97 | |
| SCHEMBL3467771 | 0.76 | KIF11 (0.48) | KIF11RXRAP2RY14CDK1KIT | |
| SCHEMBL3467252 | 0.76 | KIF11 (0.53) | KIF11CDK1KITCDK2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |