Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 9/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466406 | 0.91 | RORC (0.45) | S1PR5RORCPARP10PARP11ASIC3 | |
| SCHEMBL3468263 | 0.81 | KIF11 (0.53) | RXRARXRBRXRGKIF11 | |
| SCHEMBL3467480 | 0.74 | EGFR (0.44) | — | |
| SCHEMBL3467357 | 0.74 | AKR1C3 (0.45) | KIF11BACE1 | |
| SCHEMBL3308412 | 0.72 | KIF11 (0.53) | RORCRXRARXRBRXRGKIF11 | |
| SCHEMBL3313408 | 0.71 | KIF11 (0.62) | PARP10PARP11ASIC3KIF11 | |
| SCHEMBL3713898 | 0.71 | KMT2A (0.43) | KIF11 | |
| SCHEMBL8337601 | 0.68 | SLC13A5 (0.67) | S1PR5MMESLC13A5RXRARXRB | |
| SCHEMBL3467451 | 0.68 | OTUD7B (0.41) | PARP10PARP11 | |
| SCHEMBL4891219 | 0.68 | KIF11 (0.56) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |