Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467995 | 0.90 | DGAT1 (0.56) | CASP3SENP8SENP7SENP6MEN1 | |
| SCHEMBL29661365 | 0.89 | MAPT (0.54) | MEN1KMT2AGAAUSP2KEAP1 | |
| SCHEMBL13885068 | 0.86 | KMT2A (0.54) | MEN1KMT2AGAAUSP2KEAP1 | |
| SCHEMBL5307521 | 0.84 | CES2 (0.55) | MEN1KMT2ADGAT1AKR1C3MAPT | |
| SCHEMBL4743106 | 0.83 | MAPK1 (0.58) | MEN1KMT2AGAAUSP2KEAP1 | |
| SCHEMBL5375567 | 0.82 | MEN1 (0.68) | MEN1KMT2AGAAAKR1C3USP2 | |
| SCHEMBL7679540 | 0.82 | MEN1 (0.68) | CASP3SENP8SENP7SENP6MEN1 | |
| SCHEMBL17358779 | 0.81 | MAPT (0.67) | MEN1KMT2ADGAT1AKR1C3MAPT | |
| SCHEMBL11015067 | 0.81 | CES2 (0.48) | MEN1KMT2ADGAT1GAAUSP2 | |
| SCHEMBL3467555 | 0.81 | CASP3 (0.55) | CASP3SENP8SENP7SENP6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2866810-B9 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | UNIV MISSOURI (US) | 2019-06-26 | — | — | EP | disclosed |
| US-10143686-B2 | Oxidosqualene cyclase as a protein target for anticancer therapeutics | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2018-12-04 | — | — | US | disclosed |
| EP-2866810-B1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | UNIV MISSOURI (US) | 2018-10-03 | — | — | EP | disclosed |
| CN-103596570-B | Oxysqualene cyclase as protein targets for anticancer therapy | 密苏里大学管委会 | 2018-02-16 | — | — | CN | disclosed |
| US-20150366824-A1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2015-12-24 | — | — | US | disclosed |
| US-20150366824-A1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2015-12-24 | — | — | US | disclosed |
| US-20150366824-A1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2015-12-24 | — | — | US | disclosed |
| CN-104717967-A | Induction of estrogen receptor beta by cholesterol biosynthesis inhibitors and methods of treatment of cancer | UNIV MISSOURI | 2015-06-17 | — | — | CN | disclosed |
| EP-2866810-A1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | The Curators Of The University Of Missouri (US) | 2015-05-06 | — | — | EP | disclosed |
| CN-103596570-A | Oxysqualene cyclase as protein targets for anticancer therapy | UNIV MISSOURI | 2014-02-19 | — | — | CN | disclosed |
| WO-2000076316-A1 | METHODS RELATED TO METABOLISM OF PARASITES AND MYCOBACTERIA | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| CN-1158844-A | Tertiary amines | HOFFMANN LA ROCHE (CH) | 1997-09-10 | — | — | CN | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1103781-A | Use of phenalkylamines | HOFFMANN LA ROCHE (CH) | 1995-06-21 | — | — | CN | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366824-A1 | INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER | ESRRA, ESRRB, ESRRG | CASP3 4000/4885SENP8 2828/4885SENP7 2777/4885 |
| US-10143686-B2 | Oxidosqualene cyclase as a protein target for anticancer therapeutics | COASY, HCCS, OSBP | CASP3 3683/4885SENP8 2555/4885SENP7 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.