Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 8/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3474651 | 0.77 | TDP2 (0.47) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3471027 | 0.72 | TDP2 (0.62) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3471238 | 0.72 | TDP2 (0.80) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3476272 | 0.70 | TDP2 (0.40) | TDP2ALDH1A1KDM4EMAPTCRHBP | |
| SCHEMBL3471243 | 0.69 | HSF1 (0.42) | TDP2ALDH1A1KDM4EMAPTCASP6 | |
| SCHEMBL3473639 | 0.68 | TDP2 (0.58) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3475005 | 0.68 | TDP2 (0.56) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3472489 | 0.68 | TDP2 (0.57) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3471919 | 0.67 | TDP2 (0.75) | TDP2KDM4CRAF1MAP2K1ALDH1A1 | |
| SCHEMBL3472457 | 0.64 | TDP2 (0.40) | TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | claimed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |