Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 11/20 | 0.75 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.75 |
| ▸ | CASP6 | P55212 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13272610 | 0.86 | TDP2 (1.00) | TDP2KDM4CCASP6CASP7KDM4E | |
| SCHEMBL3471027 | 0.81 | TDP2 (0.62) | TDP2KDM4CCASP6CASP7NSD2 | |
| SCHEMBL3471912 | 0.79 | TDP2 (0.66) | TDP2KDM4CCASP6CRHBPCRHR2 | |
| SCHEMBL3471238 | 0.78 | TDP2 (0.80) | TDP2KDM4CCASP7KDM4EMAPT | |
| SCHEMBL3473639 | 0.77 | TDP2 (0.58) | TDP2KDM4CCASP6CASP7NSD2 | |
| SCHEMBL3474479 | 0.74 | TDP2 (1.00) | TDP2KDM4CCASP6CASP7KDM4E | |
| SCHEMBL3471911 | 0.73 | TDP2 (0.77) | TDP2KDM4CCASP6CASP7KDM4E | |
| SCHEMBL3471993 | 0.72 | TDP2 (0.73) | TDP2KDM4CCASP6CASP7KDM4E | |
| SCHEMBL3475916 | 0.68 | TDP2 (0.67) | TDP2KDM4CKDM4EMAPTLMNA | |
| SCHEMBL14020030 | 0.67 | TDP2 (0.73) | TDP2KDM4CCASP6CASP7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |