Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314291 | 0.92 | BRD4 (0.42) | METCYP11B1CYP11B2PARP10PARP11 | |
| SCHEMBL3306832 | 0.92 | MET (0.47) | METCYP11B1CYP11B2CYP1A2MAPT | |
| SCHEMBL3306622 | 0.85 | CYP11B1 (0.46) | METCYP11B1CYP11B2CYP1A2PARP10 | |
| SCHEMBL3308636 | 0.84 | MET (0.45) | METCYP11B1CYP11B2CYP1A2MAPT | |
| SCHEMBL14866024 | 0.83 | MET (0.48) | METCYP11B1CYP11B2CYP1A2MAPT | |
| SCHEMBL3301564 | 0.81 | MET (0.47) | METCYP11B1CYP11B2CYP1A2MAPT | |
| SCHEMBL3473348 | 0.81 | MET (0.47) | METCYP11B1CYP11B2CYP1A2MEN1 | |
| SCHEMBL30393232 | 0.80 | CYP11B1 (0.41) | METCYP11B1CYP11B2CYP1A2HRH3 | |
| SCHEMBL3308428 | 0.78 | CYP11B1 (0.42) | METCYP11B1CYP11B2KMT2AHDAC6 | |
| SCHEMBL14866213 | 0.78 | CCKBR (0.48) | METMAPTCCKBRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |