Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099850 | 0.93 | ALDH1A1 (0.49) | MAPTALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL1099865 | 0.89 | MAPT (0.57) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL2144861 | 0.74 | MAPT (0.50) | MAPTALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL1593116 | 0.74 | MAPK1 (0.47) | MAPTALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL27859524 | 0.73 | KMT2A (0.35) | MAPTALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL4763106 | 0.72 | KMT2A (0.45) | MAPTALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL12253486 | 0.71 | SLC9A1 (0.56) | MAPTALDH1A1LMNAL3MBTL1KMT2A | |
| SCHEMBL1593717 | 0.70 | MAPT (0.51) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1593401 | 0.70 | MAPT (0.51) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL3380500 | 0.70 | L3MBTL1 (0.52) | MAPTALDH1A1L3MBTL1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010072599-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |