Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.67 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.67 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571583 | 0.88 | MEN1 (0.63) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL30218132 | 0.88 | TSHR (0.58) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL15647549 | 0.88 | NFKBIA (0.61) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL23832700 | 0.88 | TSHR (0.58) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL25754724 | 0.86 | L3MBTL1 (0.61) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL2241186 | 0.86 | ALPL (0.60) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL27181384 | 0.85 | KMT2A (0.80) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL7572373 | 0.84 | L3MBTL1 (0.67) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL15821362 | 0.83 | L3MBTL1 (0.55) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL7571516 | 0.83 | NFKBIA (0.62) | SMN1; SMN2MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | SMN1; SMN2 4488/4885MEN1 4481/4885KMT2A 1141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.