Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.36 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923409 | 0.88 | KDM4E (0.39) | ALDH1A1KDM4EPOLBHPGDTDP1 | |
| SCHEMBL2512853 | 0.86 | METTL3 (0.45) | ALDH1A1KDM4EPOLBHPGDL3MBTL1 | |
| SCHEMBL3470749 | 0.83 | KDM4E (0.38) | ALDH1A1KDM4EHPGDDAGLAABHD6 | |
| SCHEMBL4166535 | 0.80 | DAGLB (0.43) | ALDH1A1KDM4EPOLBHPGDTDP1 | |
| SCHEMBL4163082 | 0.78 | KDM4E (0.54) | ALDH1A1KDM4EHPGDDAGLAABHD6 | |
| SCHEMBL27808115 | 0.78 | KDM4E (0.54) | ALDH1A1KDM4EHPGDDAGLAABHD6 | |
| SCHEMBL3676086 | 0.78 | KDM4E (0.56) | ALDH1A1KDM4EPOLBHPGDNPC1 | |
| SCHEMBL4153904 | 0.77 | MCHR1 (0.42) | ALDH1A1KDM4EPOLBHPGDDAGLA | |
| SCHEMBL2490542 | 0.77 | HCRTR2 (0.43) | POLBHCRTR2HCRTR1 | |
| SCHEMBL3251052 | 0.76 | PDE8B (0.38) | ALDH1A1KDM4EPOLBHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072722-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | WO | disclosed |