Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | EIF4E | P06730 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092693 | 0.83 | KDM4E (0.39) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3093212 | 0.80 | KDM4E (0.43) | LMNAKDM4ESMN1; SMN2MAPTKMO | |
| SCHEMBL5717729 | 0.80 | LMNA (0.51) | LMNAKDM4ESMN1; SMN2MAPTKMO | |
| SCHEMBL4900754 | 0.77 | LMNA (0.45) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3100563 | 0.77 | MAPT (0.43) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL6477011 | 0.77 | ALDH1A1 (0.51) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL15014149 | 0.77 | MAPT (0.45) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3542428 | 0.76 | LDHA (0.57) | LMNAKDM4ESMN1; SMN2KMORAB9A | |
| SCHEMBL4894623 | 0.76 | LMNA (0.46) | LMNAKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL4904153 | 0.74 | MAPT (0.56) | LMNAKDM4ESMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |
| EP-2172450-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |