Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.59 |
| ▸ | BCL2A1 | Q16548 | 5/20 | 0.59 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265536 | 1.00 | BCL2 (0.59) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL15107497 | 0.93 | BCL2 (0.56) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL15107498 | 0.93 | BCL2 (0.56) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL2757180 | 0.89 | BCL2 (0.48) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL3265681 | 0.87 | BCL2L1 (0.79) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL2757197 | 0.83 | BCL2L1 (0.73) | BCL2BCL2L1MCL1BCL2A1BAK1 | |
| SCHEMBL3472763 | 0.81 | TAAR1 (0.58) | BCL2BCL2L1MCL1BCL2A1MAPT | |
| SCHEMBL3474066 | 0.79 | KMT2A (0.52) | MCL1MAPTTDP1ALDH1A1POLB | |
| SCHEMBL3473276 | 0.76 | ADORA2A (0.49) | TP53MAPTALDH1A1 | |
| SCHEMBL3471960 | 0.75 | BCL2 (0.55) | BCL2BCL2L1MCL1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487131-B2 | Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2) | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-07-16 | — | — | US | disclosed |
| US-8436207-B2 | Naphthalene-based inhibitors of anti-apoptotic proteins | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-05-07 | — | — | US | disclosed |
| US-20100267781-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267781-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | HAX1, BAX, APOL1 | BCL2 11/4885BCL2L1 20/4885MCL1 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.