Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | BCL2 | P10415 | 3/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.57 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471236 | 0.91 | MAPT (0.51) | TAAR1BCL2BCL2L1MCL1BCL2A1 | |
| SCHEMBL3471000 | 0.81 | BCL2 (0.59) | BCL2BCL2L1MCL1BCL2A1NPC1 | |
| SCHEMBL3265536 | 0.81 | BCL2 (0.59) | BCL2BCL2L1MCL1BCL2A1NPC1 | |
| SCHEMBL3474066 | 0.81 | KMT2A (0.52) | MCL1MAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL353840 | 0.78 | BCL2 (0.48) | BCL2BCL2L1MCL1BCL2A1KDM4E | |
| SCHEMBL353111 | 0.77 | TACR3 (0.54) | SMN1; SMN2ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL3471960 | 0.76 | BCL2 (0.55) | BCL2BCL2L1MCL1NPC1MAPT | |
| SCHEMBL353909 | 0.76 | MEN1 (0.43) | MAPTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL15107497 | 0.76 | BCL2 (0.56) | BCL2BCL2L1MCL1BCL2A1NPC1 | |
| SCHEMBL15107498 | 0.76 | BCL2 (0.56) | BCL2BCL2L1MCL1BCL2A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418942-B1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | SANFORD-BURNHAM MEDICAL RES INST (US) | 2017-08-23 | — | — | EP | disclosed |
| US-8436207-B2 | Naphthalene-based inhibitors of anti-apoptotic proteins | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-05-07 | — | — | US | disclosed |
| US-20100267781-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267781-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | HAX1, BAX, APOL1 | TAAR1 4231/4885BCL2 11/4885BCL2L1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.