Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120300 | 0.88 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CA12CA1CA2 | |
| SCHEMBL14593012 | 0.88 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2CYP1A2TSHRCYP2C19 | |
| SCHEMBL941127 | 0.87 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL1495720 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2CYP1A2TSHRCYP2C19 | |
| SCHEMBL7621544 | 0.82 | HSD17B2 (0.58) | ALDH1A1SMN1; SMN2TSHRCA12CA1 | |
| SCHEMBL21032196 | 0.81 | CA1 (0.50) | ALDH1A1SMN1; SMN2CYP1A2CA12CA1 | |
| SCHEMBL9879781 | 0.81 | LMNA (0.53) | ALDH1A1CYP1A2CA12CA1CA2 | |
| SCHEMBL3165834 | 0.81 | CA1 (0.50) | ALDH1A1SMN1; SMN2CYP1A2CA12CA1 | |
| SCHEMBL3256021 | 0.80 | CA12 (0.61) | ALDH1A1SMN1; SMN2CYP1A2TSHRCA12 | |
| SCHEMBL19682940 | 0.80 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP1A2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| WO-2010127246-A2 | HNF4 MODULATORS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | ALDH1A1 810/4885SMN1; SMN2 4488/4885CYP1A2 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.