Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.53 |
| ▸ | RET | P07949 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27738017 | 0.88 | RXRA (0.53) | RXRANR1H2NR1H3 | |
| Tert-Butyl Formate SCHEMBL27738020 | 0.83 | RXRA (0.52) | RXRANR1H2NR1H3RET | |
| SCHEMBL3475014 | 0.82 | RXRA (0.56) | RXRANR1H2NR1H3RET | |
| SCHEMBL3471163 | 0.82 | RXRA (0.56) | RXRANR1H2NR1H3MAPT | |
| SCHEMBL3471878 | 0.82 | RXRA (0.51) | RXRANR1H2NR1H3 | |
| SCHEMBL12979225 | 0.79 | JAK2 (0.49) | RXRANR1H2NR1H3MAPT | |
| SCHEMBL3584004 | 0.78 | RET (0.47) | RETPGK1CKS1BSKP1SKP2 | |
| SCHEMBL3469858 | 0.77 | MEN1 (0.53) | RXRANR1H2NR1H3MAPTMEN1 | |
| SCHEMBL3472699 | 0.76 | RXRA (0.66) | RXRANR1H2NR1H3 | |
| SCHEMBL2256339 | 0.75 | GPR119 (0.47) | RETPGK1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | claimed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.