Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TPO | P07202 | 1/20 | 0.39 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456302 | 0.82 | LMNA (0.41) | MAPTTP53CCR2SCN7AKCNH2 | |
| SCHEMBL345563 | 0.82 | NAMPT (0.46) | MAPTTP53KMOSCN7AKCNH2 | |
| SCHEMBL29456267 | 0.78 | MAPK9 (0.52) | CCR2 | |
| SCHEMBL21196908 | 0.78 | SCN7A (0.55) | KMOCCR2SCN7AKCNH2 | |
| SCHEMBL3782016 | 0.78 | MAPK9 (0.52) | CCR2 | |
| SCHEMBL30042221 | 0.78 | KMO (0.39) | MAPTTP53KMOKMT2ACCR2 | |
| SCHEMBL29456342 | 0.77 | MAPK9 (0.46) | MAPTSCN7AKCNH2 | |
| SCHEMBL3452902 | 0.76 | TDP1 (0.41) | MAPTTP53CCR2MPOTPO | |
| SCHEMBL29456068 | 0.75 | MAPK8 (0.49) | KMT2A | |
| SCHEMBL2795278 | 0.75 | PTGER4 (0.37) | MAPTTP53KMOCCR2OXER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | claimed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | claimed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | claimed |
| US-20220081427-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2022-03-17 | — | — | US | disclosed |
| US-20200277285-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2020-09-03 | — | — | US | disclosed |
| US-20180319780-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2018-11-08 | — | — | US | disclosed |
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | disclosed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081427-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | MAPT 51/4885TP53 350/4885KMO 1604/4885 |
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | AQP4, PMP22, CHRNA2 | MAPT 153/4885TP53 4808/4885KMO 767/4885 |
| US-20200277285-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | MAPT 51/4885TP53 350/4885KMO 1604/4885 |
| US-20180319780-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | MAPT 51/4885TP53 350/4885KMO 1604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.