Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.35 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470788 | 0.84 | RXRA (0.57) | RXRANR1H2NR1H3RETGUCY1B2 | |
| SCHEMBL2390342 | 0.78 | RXRA (0.61) | RXRANR1H2NR1H3DPP4ALK | |
| SCHEMBL3471298 | 0.75 | RXRA (0.63) | RXRANR1H2NR1H3GUCY1B2GUCY1A2 | |
| SCHEMBL3472176 | 0.74 | RXRA (0.72) | RXRANR1H2NR1H3GUCY1B2GUCY1A2 | |
| SCHEMBL3475014 | 0.74 | RXRA (0.56) | RXRANR1H2NR1H3ALKRET | |
| SCHEMBL3474540 | 0.74 | RXRA (0.69) | RXRANR1H2NR1H3KCNK3 | |
| SCHEMBL3471757 | 0.73 | RXRA (1.00) | RXRANR1H2NR1H3KCNK3 | |
| SCHEMBL3473492 | 0.71 | RXRA (0.70) | RXRANR1H2NR1H3KCNK3 | |
| SCHEMBL2390508 | 0.68 | RXRA (0.51) | RXRANR1H2NR1H3ALKRET | |
| SCHEMBL2389417 | 0.68 | RXRA (0.61) | RXRANR1H2NR1H3RETWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | claimed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| CN-101248048-B | Imidazole based LXR modulators | EXELIXIS INC | 2013-08-28 | — | — | CN | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.