Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472326 | 0.92 | RXRA (0.60) | RXRANR1H2NR1H3CCR1IRAK4 | |
| SCHEMBL3472666 | 0.91 | RXRA (0.59) | RXRANR1H2NR1H3CCR1IRAK4 | |
| SCHEMBL3474945 | 0.86 | RXRA (0.61) | RXRANR1H2NR1H3 | |
| SCHEMBL3472596 | 0.84 | RXRA (0.66) | RXRANR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL12979545 | 0.84 | NR1H2 (0.66) | RXRANR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL3472821 | 0.82 | RXRA (0.63) | RXRANR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL3471265 | 0.82 | RXRA (0.53) | RXRANR1H2NR1H3 | |
| SCHEMBL15230208 | 0.80 | NR1H2 (0.61) | RXRANR1H2NR1H3HSD17B10HSD17B1 | |
| SCHEMBL16455318 | 0.80 | NR1H2 (0.60) | RXRANR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL15242996 | 0.80 | NR1H2 (0.60) | RXRANR1H2NR1H3HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140148467-A1 | Carboxamide Compounds and Methods for Using the Same | RIGEL PHARMACEUTICALS, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148467-A1 | Carboxamide Compounds and Methods for Using the Same | PC, AK2, PRKAA2 | RXRA 285/4885NR1H2 926/4885NR1H3 1172/4885 |
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.