Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347317 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL4923629 | 0.81 | MAPT (0.56) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL773420 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL27957021 | 0.79 | MAPT (0.54) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL4914698 | 0.78 | KMT2A (0.53) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL4924626 | 0.77 | MAPT (0.76) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL4765972 | 0.77 | NPC1 (0.76) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL27257810 | 0.75 | KDM4E (0.52) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL2493886 | 0.74 | MAPK13 (0.57) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL4914715 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318949-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-11-27 | — | — | US | disclosed |
| US-20120014906-A1 | ORGANIC COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2012-01-19 | — | — | US | disclosed |
| US-8049016-B2 | Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes | NOVARTIS AG (CH) | 2011-11-01 | — | — | US | disclosed |
| US-20090264444-A1 | Organic compounds | XENON PHARMACEUTICALS INC. (CA) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120014906-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | SMN1; SMN2 3581/4885HPGD 344/4885MAPT 2947/4885 |
| US-20090264444-A1 | Organic compounds | SCD, SCD5, FADS2 | SMN1; SMN2 3581/4885HPGD 344/4885MAPT 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.