Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ASPH | Q12797 | 1/20 | 0.51 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491213 | 0.78 | RAB9A (0.54) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL4252563 | 0.75 | MAPK14 (0.74) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL347316 | 0.74 | SMN1; SMN2 (0.52) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL347317 | 0.74 | SMN1; SMN2 (0.52) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL16634682 | 0.72 | HCAR3 (0.58) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL16634686 | 0.72 | HCAR3 (0.58) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL453183 | 0.71 | AKR1C3 (0.68) | KDM4EASPHKDM8ALDH1A1MAPT | |
| SCHEMBL5634010 | 0.71 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL397773 | 0.71 | MAPK1 (0.77) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL31039816 | 0.71 | LCK (0.63) | MAPK13MAPK12MAPK11MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102256972-A | Thiazolyl-benzimidazoles | HOFFMANN LA ROCHE | 2011-11-23 | — | — | CN | disclosed |
| EP-2379543-A2 | THIAZOLYL-BENZIMIDAZOLES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| US-8044213-B2 | Thiazolyl-benzimidazoles | HOFFMANN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| WO-2010121675-A2 | THIAZOLYL-BENZIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CAI JIANPING | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CYP3A7, CYP2C19, CYP3A5 | MAPK13 2840/4885MAPK12 3535/4885MAPK11 3003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.