Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.95 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.85 |
| ▸ | SLCO1B3 | Q9NPD5 | 3/20 | 0.85 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.85 |
| ▸ | USP2 | O75604 | 3/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.85 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | TP53 | P04637 | 1/20 | 0.85 |
| ▸ | MAPT | P10636 | 1/20 | 0.85 |
| ▸ | HPGD | P15428 | 1/20 | 0.85 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.85 |
| ▸ | RECQL | P46063 | 1/20 | 0.85 |
| ▸ | BLM | P54132 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.79 |
| ▸ | MLNR | O43193 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Erythromycin SCHEMBL7597008 | 0.97 | ABCB11 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin SCHEMBL7597003 | 0.97 | ABCB11 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin SCHEMBL11319270 | 0.97 | ABCB11 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin SCHEMBL11319266 | 0.97 | ABCB11 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL7596572 | 0.94 | ABCB11 (0.94) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL7596567 | 0.94 | ABCB11 (0.94) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin Propionate SCHEMBL25223334 | 0.92 | CYP3A4 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin Propionate SCHEMBL29400629 | 0.92 | CYP3A4 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin Propionate SCHEMBL3331 | 0.92 | CYP3A4 (1.00) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 | |
| Erythromycin SCHEMBL28256019 | 0.92 | ABCB11 (0.86) | ABCB11ABCC4CYP3A4SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108379087-A | Filling paste for dental pulp conservation treatment and preparation method thereof | 徐崇明 | 2018-08-10 | — | — | CN | claimed |
| CN-107441501-A | Drug-loaded liposome of antibacterial peptide modification and its production and use | 四川大学 | 2017-12-08 | — | — | CN | claimed |
| CN-107446019-A | Antibacterial peptide derivative and application thereof | 四川大学 | 2017-12-08 | — | — | CN | claimed |
| CN-107320727-A | Antibacterial peptide and antibiotic combinations antibacterials and its application method | 四川大学 | 2017-11-07 | — | — | CN | claimed |
| CN-105492005-A | Methods of treating microbial infections including mastitis | LUODA PHARMA PTY LTD | 2016-04-13 | — | — | CN | claimed |
| CN-105492004-A | Method of treating topical microbial infections | LUODA PHARMA PTY LTD | 2016-04-13 | — | — | CN | claimed |
| CN-103705988-B | A kind of intramedullary pin with multi-functional coatings and preparation method thereof | SHANGHAI MICROPORT ORTHOPEDICS CO., LTD. (CN) | 2016-02-17 | — | — | CN | claimed |
| CN-103705988-A | Intramedullary nail having multifunctional coating and preparation method | SHANGHAI MICROPORT ORTHOPEDICS | 2014-04-09 | — | — | CN | claimed |
| US-20100221245-A1 | TOPICAL SKIN CARE COMPOSITION | DERMADOCTOR, LLC | 2010-09-02 | — | — | US | claimed |
| CN-101039668-A | Pharmaceutical formulations comprising an antibiotic, a triazole and a corticosteroid | SCHERING PLOUGH LTD (CH) | 2007-09-19 | — | — | CN | claimed |
| CN-1084631-C | Powder medicine made of Chinese and Western medicines for treating toothache and preparation process thereof | ZHANG CHANGLIANG (CN) | 2002-05-15 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| CN-1285220-A | Powder medicine made of Chinese and Western medicines for treating toothache and preparation process thereof | ZHANG CHANGLIANG (CN) | 2001-02-28 | — | — | CN | claimed |
| CN-1031326-A | Method with haloplankton as living drug carrier control fish and shrimp diseases | QINGDAO OCEAN UNIVERSITY (CN) | 1989-03-01 | — | — | CN | claimed |
| EP-3897452-B1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA INC (US) | 2024-07-03 | — | — | EP | disclosed |
| US-20230201610-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| US-11612754-B2 | Resorbable nonwoven pouches for medical device implants | TEPHA, INC. (US) | 2023-03-28 | — | — | US | disclosed |
| US-4539234-A | Urethral catheter capable of preventing urinary tract infection and process for producing the same | UNITIKA LTD. (JP) | 1985-09-03 | — | — | US | disclosed |
| US-4335115-A | ERYTHROMYCIN, GLYCEROL MONOOLEATE, ETHANOL, AND ISOPROPYL MYRISTATE | THE PROCTER & GAMBLE COMPANY (US) | 1982-06-15 | — | — | US | disclosed |
| US-4102806-A | DISPERSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-25 | — | — | US | disclosed |